Preliminary Program

 

INTERNATIONAL MOTONEURON MEETING - ISTANBUL 2016

(Preliminary Program)

 

Monday 20 June 2016

VENUE for reception: Sevgi Gönül Auditorium

17:00 – 19:00 Welcome reception and registration

 

Tuesday 21 June 2016

VENUE for the rest of the meeting is SOS208 Auditorium

08:00 – 08:45 Registration and breakfast 

08:45 – 09:00 Welcome: Kemal Türker, Koç University, Istanbul, Turkey

 

Session 1: Introductory session - Chair: Rob Brownstone

09:00 - 09:30 Elif Vatanoğlu-Lutz Yeditepe University, Istanbul, Turkey

A brief history of medicine and neuroscience in Anatolia


09:30 – 10:00 Simon Gandevia, Neuroscience Research Australia, Sydney, Australia

The use and abuse of different forms of brain stimulation to modulate human corticospinal excitability


10:00 – 10:30 Dario Farina, University Medical Center Göttingen, Göttingen, Germany

Analysis of the behavior of large populations of motor units in humans by high-density electrode system


10:30 – 11:00 Hans Hultborn, University of Copenhagen, Denmark

Advances/problems in our understanding of how motoneurons convert input to output 

 

11:00 – 11:30 Morning tea, coffee, cakes

 

Session 2:  Motoneuron / motor unit properties – Chair: Hans Hultborn

11:30 – 11:50 Francesco Negro, University Medical Center Göttingen, Göttingen, Germany

Control of motor units by low-frequency common input


11:50 – 12:10 Rob Brownstone, University College London

C-bouton regulation of MN excitability


12:10 – 12:30 Antonny Czarnecki, CNRS UMR, Paris, France

Persistent sodium current controls motoneuron and Renshaw cell excitability at the onset of synptogenesis in the mouse embryonic spinal cord

 

12:30 – 14:00 Lunch: Follow the volunteers wearing Meeting T-shirts

 

Session 3: Neuromodulatory effects on motor output, from mechanisms to functional effects – Chair: Daniel Zytnicki

14:00 – 14:20 Randall K Powers, University of Washington, Seattle, USA

Distortion of motor commands by motoneuron pool properties


14:20 – 14:40 CJ Heckman, Northwestern University, Chicago, USA

Gain control in motoneurons, from cellular effects to system outputs


14:40 – 15:00 Christopher Thompson, Temple University, Philadelphia, USA

Post synaptic potentials across motoneuron populations in the cat

 

15:00 – 15:30 Afternoon tea, coffee, cakes

 

Session 4 - Posters (rest of the afternoon) Chair: CJ Heckman

15:30 – 17:30

POSTER SESSION: ALL POSTERS WILL BE BRIEFLY PRESENTED USING A MAXIMUM OF 2 SLIDES AND WITHIN 3 MINUTES

POSTERS WILL THEN BE DISPLAYED OUTSIDE THE MEETING ROOM ON THE 21ST AND 22ND OF JUNE

 

Wednesday 22 June 2016

08:00 – 09:00 Breakfast and Posters

 

Session 5: Stimulus evoked Post-synaptic potentials in human motoneurons-Chair: Simon Gandevia

09:00 – 09:20 Kemal Türker, Koç University, Istanbul, Turkey

A brief history of the peristimulus frequencygram


09:20 – 09:40 Monica Gorassini, University of Alberta, Canada

The use of peristimulus frequencygrams to examine sensory activation of motoneurons in health and neurotrauma


09:40 – 10:00 Gizem Yılmaz, Koç University, Sarıyer, Istanbul, Turkey

Periodontal and muscle spindle pathways to the trigeminal motoneurons


10:00 – 10:20 Utku Ş. Yavuz, University Medical Center Göttingen, Göttingen, Germany

Reflex responses of large populations of motor units as a means to estimate the distribution of afferent input

 

10:30 – 11:00 Morning tea, coffee, cakes

 

Session 6: Motoneurons in general – Chair: Monica Gorassini

11:00 – 11:20 Jacques Durand, CNRS-AMU, Marseilles, France

A review of 40 years of NMDA receptors in motoneurons: where, when and why?


11:20 – 11:40 Amr Mahrous and Sherif Elbasiouny; Wright State University, USA

The role of SK channels in initiating motoneuron bursting in the spinal cord


11:40 – 12:00 Anna Kaczmarek, Svenja Schneider, Laura Torres-Benito, Vanessa Grysko, Aaradhita Upadhyay, Markus Riessland, Kathryn J. Swoboda, Brunhilde Wirth; University of Cologne, Germany; The Rockefeller University and Massachussets General Hospital for Children, USA

SMA modifier mod2 improves motor neuron length and neuromuscular junction size

 

12:00 – 13:30 Lunch: Follow the volunteers wearing Meeting T-shirts

 

Session 7: Motoneurons in ALS: (rest of the afternoon) – Chair: A. Nazlı Başak

13:30 – 13:50 A. Nazlı Başak, Boğaziçi University, Istanbul, Turkey

The distinct genetics of ALS in Turkey


13:50 – 14:10 Claire Meehan, University of Copenhagen, Denmark

What can we learn from the G127X mouse SOD1 mouse model of amyotrophic lateral sclerosis?


14:10 – 14:30 Mingchen C. Jiang and Charles J. Heckman Departments of Physiology, Physical Medicine and Rehabilitation and Physical Therapy and Human Movement Sciences, Northwestern University Feinberg School of Medicine, Chicago, USA

Spontaneous synaptic excitation in spinal motoneurons in an adult mouse model of amyotrophic lateral sclerosis


14:30 – 14:50 Baris Isak, Hatice Tankisi, Kirsten Pugdahl, Birger Johnsen, Nanna Brix Finnerup, Páll Karlsson, Jasna Furtula, Anders Fuglsang-Frederiksen; Aarhus University, Denmark

Sensory involvement in amyotrophic lateral sclerosis


14:50 – 15:10 M Hadzipasic, Yale School of Medicine, New Haven, USA

Loss of high frequency motoneuron output produces intraburst EMG variability in awake walking ALS mice

 

15:10 – 15:40 Afternoon tea, coffee, cakes

 

15:40 – 16:00 Marcin Bączyk, Paris Descartes University, CNRS, Paris, France

Monosynaptic excitatory inputs to spinal motoneurons are depressed in SOD1-G93A mice, model of amyotrophic lateral sclerosis


16:00 – 16:20 L. Martinez-Silva, CNRS / Univ. Paris Descartes, Paris, France

Excitability of adult spinal motor neurons in the fus-p525l model of amyotrophic lateral sclerosis (ALS)


16:20 – 16:40 Anton Filipchuk, Fanny Gaudel, Cécile Brocard, Sylvie Liabeuf, Jacques Durand, Institute of Neurosciences Timone, Marseille, France

Early pathological signs in presymptomatic motoneurons in ALS transgenic mice


16:40 – 17:00 Mamede de Carvalho, Peter M. Andersen,  Julian Grosskreutz, Magdalena Kuźma-Kozakiewicz, Susanne Petri-Mals, Maria Piotrkiewicz, Teresa Podsiadły-Marczykowska, University of Lisbon, Portugal, Umeå University, Umeå, Sweden, University Hospital Jena, Germany, Medical University of Warsaw, Poland, Hannover Medical School, Hannover, Germany, Nalecz Institute of Biocybernetics and Biomedical Engineering, Warsaw, Poland

ONWebDUALS: the European project funded by national agencies under the patronage of Joint Programme – Neurodegenerative Disease Research (JPND)


17:00 – 17:20 Vibhu Sahni , Sara J. Shnider, Denis Jabaudon , Janet Song, and Jeffrey D. Macklis, Geneva University Hospital, Geneva, Switzerland

Molecular development of corticospinal connectivity: Implications for organization of

motor control circuitry and motor neuron disease

 

Thursday 23 June 2016

08:00 – 09:00 Breakfast and Posters

 

Session 8: Motoneurons and sports sciences - Chair: Inge Zijdewind

09:00 – 09:20 Krutki Piotr, Mrówczyński Włodzimierz, Bączyk Marcin, Łochyński Dawid, Celichowski Jan, Poznan University of Physical Education, Poland

Adaptations in electrophysiological properties of motoneurons after weight-lifting training in rats


09:20 – 09:40 Jan Celichowski, Dawid Łochyński, Dominik Kaczmarek, Włodzimierz Mrówczyński, Wojciech Warchoł, Joanna Majerczak, Janusz Karasiński, Michal Korostynski, Jerzy Zoladz, Poznań University of Physical Education, Poland and University School of Physical Education, Kraków, Poland

Contractile properties of motor units and expression of myosin heavy chain isoforms in rat fast muscle after weight-lifting training

 

Session 9: Motoneurons in Parkinson's disease and Cerebral Palsy - Chair: Claire Meehan

09:40 – 10:00 Jessica M. Wilson, Northwestern University, Chicago, USA

Facilitation of motoneuron excitability in Parkinson’s disease


10:00 – 10:20 Katharina Quinlan, Alexander Drobyshevsky, Northwestern Feinberg School of Medicine; University of Chicago, Chicago, USA

Serotonin sensitivity of spinal motoneurons from hypoxia-ischemia rabbit model of cerebral palsy

 

10:30 – 11:00 Morning tea, coffee, cakes

 

Session 10: Motoneurons in spinal cord injury and stroke – Chair: Randall Powers

11:00 – 11:20 Jayne Garland, Western University, Canada

Robot-assisted therapy plus repetitive TMS improves motor unit activation post-stroke


11:20 – 11:40 X Hu, WZ Rymer, N Suresh, Rehabilitation Institute of Chicago, Chicago, USA.

Neural origins of muscle weakness in hemispheric stroke survivors


11:40 – 12:00 K.P. Dimintiyanova, J. Wienecke, D.B. Jensen, C.F. Meehan, University of Copenhagen, Denmark.

The time course of axon initial segment plasticity following spinal cord injury in rats


12:00 – 12:20 Roeland F. Prak, Christine K. Thomas, Marga Tepper, Inge Zijdewind, University Medical Center Groningen, University of Groningen, The Netherlands; University of Miami Miller School of Medicine, Miami, USA

Cortical activation during a sustained maximal voluntary contraction with the first

dorsal interosseous weakened by spinal cord injury

 

12:20 – 12:30 Closing Ceremony, oral and poster presentation prizes

 

12:30 – 14:00 Lunch: Follow the volunteers wearing Meeting T-shirts

 

17:00 – 22:00 BOSPHORUS BOAT TOUR AND GALA DINNER

 

POSTERS

 

Goltash S, Jakobsen MH, Lehnhoff J, Dimintiyanova KP, Grøndahl LK, Meehan CF; Copenhagen University, Denmark

The effects of aging on spinal motoneurones in aged c57bl/6j mouse

 

Cengiz Tataroğlu, Adnan Menderes University, Aydın, Turkey

Long latency reflexes obtained from trapezius in patients with Parkinson’s disease and cerebellar dysfunction

 

Bożenna Kuraszkiewicz, Jia-Jin Jason Chen, Hanna Goszczyńska, Maria Piotrkiewicz, Nalecz Institute of Biocybernetics and Biomedical Engineering, Poland and National Cheng Kung University, Taiwan

Bilateral changes in afterhyperpolarization duration of spinal motoneurons in post-stroke spastic patients

 

Hanna Drzymała-Celichowska, Piotr Krutki,  Rositsa Raikova, Piotr Kaczmarek, Jan Celichowski; Poznan University of Physical Education and Poznań University of Technology, Poland; Institute of Biophysics and Biomedical Engineering, Bulgaria

Slow motor units of rat soleus muscle: Sex differences and force summation

 

Katarzyna Kryściak, Jakub Kryściak, Dawid Łochyński, Dominik Kaczmarek, Hanna Drzymała-Celichowska, Piotr Krutki, Jan Celichowski; Poznan University of Physical Education, Poland

Adaptation of motor units contractile properties to the treadmill endurance training

 

Gözde Koç, Serkan Uslu, Tunca Nüzket, Hilmi Uysal; Akdeniz University, Turkey

A comparison of motor unit size index and muscle strength in elite athletes

 

Ceren Tunca, Cemre Coşkun, Cemile Koçoğlu, Fulya Akçimen, Ersin Tan, A. Nazlı Başak; Boğaziçi University and Hacettepe University, Turkey

ERLIN1 mutations as a cause of slow progressive ALS in a large Turkish pedigree

 

Fulya Akçimen, Cemile Koçoğlu, Ceren Tunca, Mustafa Ertaş, Hacer Durmuş, Yeşim Parman, A. Nazlı Başak; Boğaziçi University and Istanbul University, Turkey

Exome sequencing coupled with homozygosity mapping is a powerful combination to unravel the genetics of recessively inherited neurological diseases

 

Lahut S, Gispert S, Ömür Ö, Pirkevi C, Tireli H, Başak AN, Oertel W, Auburger G; Boğaziçi University, Memorial Hospital and Haydarpaşa Numune Training and Research Hospital, Turkey; Goethe University and Philipps University, Germany

Blood RNA biomarkers in prodromal PARK4 and RBD show role of complexin-1 loss for risk of Parkinson’s disease

 

Cemile Koçoğlu, Fulya Akçimen, Ceren Tunca, Gençer Genç, Semiha Kurt, Yeşim Parman, Derya Selçuk Demirel, Derya Kavram, A. Nazlı Başak; Boğaziçi University, Gümüşsuyu Military School, Gaziosmanpaşa University, Istanbul University, Şişli Etfal Hospital and Haydarpaşa Numune Training and Research Hospital, Turkey

Comparison of homozygosity mapping algorithms and application to recessive ataxias

 

Serkan Uslu, Tunca Nüzket, Can Özcan, Süha Yağcıoğlu, Murat Canpolat, Hilmi Uysal; Akdeniz University, Hacettepe University and Boğaziçi University, Turkey

Modified MUNIX algorithm for estimating T response motor unit number in spasticity

 

Tunca Nüzket, Serkan Uslu, Can Özcan, Süha Yağcıoğlu, Murat Canpolat, Hilmi Uysal; Akdeniz University, Hacettepe University and Boğaziçi University, Turkey

Investigation of motor unit number and size index of rectus femoris muscle in cerebral spasticity

 

M. Görkem Özyurt, Heidi Haavik, Imran Khan Niazi, Kelly Holt, Oğuz Sebik, Gizem Yılmaz, Kemal S. Türker; Koç University, Turkey; New Zealand College of Chiropractic and Auckland University of Technology, New Zealand

Spinal manipulation increases maximum bite force in healthy individuals

 

Hamid Hamzeiy, Erşen Kavak, A. Nazlı Başak; Boğaziçi University and Genomize, Turkey

Local cohort and population-specific alternative allele frequencies help drastically reduce the number of false positive variants

 

Imran Khan Niazi, Kemal S. Türker, Stanley Flavel, Mat Kinget, Jens Duehr, Heidi Haavik; New Zealand College of Chiropractic and Auckland University of Technology, New Zealand; Aalborg University, Denmark; Koç University, Turkey; University of Tasmania, Australia

Changes in H-reflex and V-waves following spinal manipulation

 

Anderson S Oliveira, Imran K Niazi, Rasmus W Nedergaard, Kelly Holt, Heidi Haavik; Aalborg University, Denmark; New Zealand College of Chiropractic, New Zealand

Changes in cortico-muscular coherence while modulating force during isometric ramp contractions

 

İlhan Karacan, Muharrem Çidem, Mehmet Çidem, Oğuz Sebik, Mustafa Görkem Özyurt, Gizem Yılmaz, Kemal S. Türker; Bağcılar Training and Research Hospital and Koç University, Turkey

Whole-body vibration induces a short or long latency muscular reflex depending on vibration acceleration

 

İsmail Bayram, Özkan Güler, A. Ruhi Soylu, Hayri Ertan; Anadolu University, Ankara University and Hacettepe University, Turkey

Muscular activation strategies of six leg muscles on stable and unstable surface

 

Paulius Uginčius, Gizem Yılmaz, Oğuz Sebik, Kemal S Türker; Lithuanian University of Health Sciences, Lithuania; Koç University, Turkey

Reflex responses of the human masseter muscle to electrical lip stimulation

 

Kemal S Türker and Mehmet C. Kahya; Koç University, Turkey

The reflex circuitry originating from the cutaneous receptors of the hand to the first dorsal interosseous muscle

 

M.G. Özyurt, G. Yılmaz, M. Dursun, M. Shabsog, S. Savran, D. Erbil, O. Sebik, K.S. Türker; Koç University, Turkey

Investigating Renshaw cell circuitry in human neuromuscular system

 

Heidi Haavik, Imran Khan Niazi, Jens Duehr, Mat Kinget, Paulius Ugincius, Oğuz Sebik, Gizem Yılmaz, Muhammad Samran Navid, Kemal S. Türker; New Zealand College of Chiropractic, New Zealand; Koç University, Turkey; Aalborg University, Denmark

Chiropractic alters TMS induced I-wave excitability and cortical silent period duration

 

Giboin Louis-Solal, Amiri Ehsan, Bertschinger Raphael, Gruber Markus; University Konstanz, Germany; Tarbiat Modares University, Iran

Fifteen minutes of active recovery after an exhaustive endurance task enhances the recovery capacity of the CNS but not that of the muscle 24h later

 

Giboin Louis-Solal, Kramer Andreas, Thomas Hassa, Mircea Ariel Schoenfeld, Christian Dettmers, Gruber Markus; Universität Konstanz, Kliniken Schmieder, Leibniz-Institut für Neurobiologie, Otto-von-Guericke University Magdeburg, Germany

Learning to walk on a slack-line induces highly task-specific neural plasticity

 

Serdar Gözler; Private Dental Practice, Istanbul, Turkey

Aggregating stimulus increases the activity in motoneurons causing spasm

 

Weisskircher, Hans-Werner, Private Dental Practice, Igel, Germany

The sensitized motoneuron as a possible missing link in the development of myofascial trigger points?